Factors Influencing Prostate Cancer

Prostate Cancer is the second most frequently diagnosed cancer and the sixth leading cause of cancer death in males. It accounts for 14% of the total new cancer cases and 6% of the total cancer deaths in males in 2008 [1]. The incidence and mortality rates were different in diverse geographic regions and racial ethnic population. But lack of consistency between studies additionally indicates that prostate cancer is a genetically heterogeneous disorder, with multiple genetic and environmental factors involved in its etiology. The cause for prostate cancer remains unknown but age and family history have some vital role in its genesis. Diagnosis of this cancer in men less than 40 years is extremely difficult but the possibility for detection rises effectively after middle age. Inflammation also may play a role in the formation of prostate cancer [2, 3]. Several proxy measures of inflammatory status, such as history of prostatitis [4], history of sexually transmitted infections [5] and genetic variation in immune response genes [6] have been associated with prostate cancer risk. Common polymorphisms in proinflammatory and anti-inflammatory cytokine genes can influence cytokine production and may play a role in prostate cancer. This review will discuss the factors influencing prostate cancer.